The 12th house rules bed pleasures, intimacy, and isolation. Ketu is the planet of spirituality, detachment, and renunciation (Sanyas).
When Ketu sits in the 12th house, it creates a massive conflict between worldly desires and spiritual detachment. Dr. Sharma reveals a humorous but tragic *Nishaniya*: this person is so detached from physical intimacy that even while lying in their marital bed, their mind is focused on God or spiritual hymns ("bhajan gaata hai").
Because they lack the desire for worldly, physical connection, they often feel trapped in domestic life. Dr. Sharma notes that a person with Ketu 12 almost always regrets getting married ("shaadi kar ke pachtata hai"), as their soul actually craves isolation.